Oncofoco Ampliado

Descrição

O teste é capaz de identificar alterações de nucleotídeo único, inserções e deleções, alterações no número de cópias gênicas e marcadores de resposta para imunoterapia (instabilidade de microssatélites e tumor mutation burden) , e fornece os resultados de forma estruturada com informações sobre alterações clinicamente relevantes, possíveis terapias específicas e ensaios clínicos disponíveis.

Genes analisados: ABL1, ABL2, ACVR1, ACVR1B, AKT1, AKT2, AKT3, ALK, AMER1, APC, AR, ARAF, ARFRP1, ARID1A, ARID1B, ARID2, ASXL1, ASXL2, ATF1, ATIC, ATM, ATR, ATRX, AURKA, AURKB, AXIN1, AXL, B2M, BAP1, BARD1, BCL10, BCL2, BCL2L1, BCL2L11, BCL2L2, BCL6, BCOR, BCORL1, BLM, BRAF, BRCA1, BRCA2, BRD3, BRD4, BRIP1, BTG1, BTK, CALR, CARD11, CASP8, CBFB, CBL, CCND1, CCND2, CCND3, CCNE1, CD274, CD79A, CD79B, CDC73, CDH1, CDK12, CDK4, CDK6, CDK8, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CEBPA, CHEK1, CHEK2, CIC, CREBBP, CRKL, CRLF2, CSF1R, CSF3R, CTCF, CTLA4, CTNNA1, CTNNB1, CUL3, CYLD, DAXX, DDR2, DDX41, DICER1, DIS3, DNMT3A, DNMT3B, DOT1L, EGFR, EIF1AX, EIF4A2, EP300, EPCAM, EPHA3, EPHA5, EPHA7, EPHB1, ERBB2, ERBB3, ERBB4, ERCC2, ERCC4, ERG, ERRFI1, ESR1, ETV1, ETV6, EWSR1, EZH2, FAM175A, FAM46C, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCL, FAS, FAT1, FBXW7, FGF10, FGF14, FGF19, FGF23, FGF3, FGF4, FGF6, FGFR1, FGFR2, FGFR3, FGFR4, FH, FLCN, FLT1, FLT3, FLT4, FOXA1, FOXL2, FOXO1, FOXP1, FRS2, FUBP1, GATA1, GATA2, GATA3, GATA6, GLI1, GNA11, GNA13, GNAQ, GNAS, GPR124, GRIN2A, GSK3B, GSTP1, H3F3A, HGF, HIST1H1C, HIST1H3B, HLA-A, HNF1A, HRAS, HSD3B1, HSP90AA1, IDH1, IDH2, IGF1R, IGF2, IKBKE, IKZF1, IL7R, INHBA, INPP4B, IRF4, IRS2, JAK1, JAK2, JAK3, JUN, KAT6A, KDM5A, KDM5C, KDM6A, KDR, KEAP1, KIF5B, KIT, KLF4, KLHL6, KMT2A, KMT2C, KMT2D, KRAS, LMO1, LRP1B, LYN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAX, MCL1, MDM2, MDM4, MED12, MEF2B, MEN1, MET, MITF, MLH1, MLL2, MLL3, MLLT10, MPL, MRE11A, MSH2, MSH6, MTOR, MUTYH, MYC, MYCL, MYCN, MYD88, MYOD1, NBN, NCOA3, NCOR1, NF1, NF2, NFE2L2, NFKBIA, NKX2-1, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NPM1, NRAS, NSD1, NTRK1, NTRK2, NTRK3, NUP93, PAK1, PAK3, PALB2, PARK2, PARP1, PAX5, PBRM1, PDGFRA, PDGFRB, PDK1, PHOX2B, PIK3C2B, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIM1, PLCG2, PMS1, PMS2, POLD1, POLE, PPARG, PPM1D, PPP2R1A, PPP6C, PRDM1, PRKAR1A, PRKDC, PRSS8, PTCH1, PTEN, PTPN11, PTPRD, PTPRT, RAB35, RAC1, RAD21, RAD50, RAD51, RAD51B, RAD51C, RAD54L, RAF1, RANBP2, RARA, RASA1, RB1, RBM10, RECQL4, REL, RET, RHEB, RHOA, RICTOR, RIT1, RNF43, ROS1, RPTOR, RUNX1, RUNX1T1, SDHA, SDHB, SDHC, SDHD, SETBP1, SETD2, SF3B1, SMAD2, SMAD3, SMAD4, SMARCA4, SMARCB1, SMO, SNCAIP, SOCS1, SOX10, SOX2, SOX9, SPEN, SPOP, SRC, SRSF2, STAG2, STAT3, STAT4, STAT5B, STK11, SUFU, SYK, TAF1, TBX3, TCF3, TERT, TET1, TET2, TGFBR1, TGFBR2, TMPRSS2, TNFAIP3, TNFRSF14, TOP1, TOP2A, TP53, TP63, TR, TSC1, TSC2, TSHR, TYMS, U2AF1, VEGFA, VHL, WISP3, WT1, XPO1, XRCC2, YAP1, ZNF217, ZNF703, ZRSR2